Unmet Needs in Functional and Nonfunctional Pancreatic Neuroendocrine Neoplasms

Robert T Jensen; Lisa Bodei; Jaume Capdevila; Anne Couvelard; Massimo Falconi; Simona Glasberg; Günter Kloppel; Steven Lamberts; Marc Peeters; Guido Rindi; Anja Rinke; Mathias Rothmund; Anders Sundin; Staffan Welin; Nicola Fazio; The ENETS 2016 Munich Advisory Board Participants; ENETS 2016 Munich Advisory Board Participants

doi:10.1159/000494258

Unmet Needs in Functional and Nonfunctional Pancreatic Neuroendocrine Neoplasms

Neuroendocrinology. 2019;108(1):26-36. doi: 10.1159/000494258. Epub 2018 Oct 3.

Authors

Robert T Jensen¹, Lisa Bodei², Jaume Capdevila³, Anne Couvelard⁴, Massimo Falconi⁵, Simona Glasberg⁶, Günter Kloppel⁷, Steven Lamberts⁸, Marc Peeters⁹, Guido Rindi¹⁰, Anja Rinke¹¹, Mathias Rothmund¹², Anders Sundin¹³, Staffan Welin¹⁴, Nicola Fazio¹⁵; The ENETS 2016 Munich Advisory Board Participants; ENETS 2016 Munich Advisory Board Participants

Collaborators

Detlef Bartsch¹⁶, Rudolf Arnold¹⁷, Eric Baudin¹⁸, Lisa Bodei¹⁹, Ivan Borbath²⁰, Jaume Capdevila²¹, Martyn Caplin²², Jie Chen²³, Frederico Costa²⁴, Anne Couvelard²⁵, Jaroslaw Ćwikła²⁶, Philippa Davies, Herder de²⁷, Massimo Falconi²⁸, Jenny Falkerby²⁹, Nicola Fazio³⁰, Diego Ferone³¹, Andrea Frilling³², Rocio Garcia-Carbonero³³, Simona Glasberg, Vera Gorbunova, Ashley Grossman³⁴, Dieter Hörsch³⁵, Robert Jensen³⁶, Gregory Kaltsas³⁷, Günter Klöppel³⁸, Ulrich Knigge³⁹, Beata Kos-Kudła⁴⁰, Guenter Krejs⁴¹, Eric Krenning⁴², Matthew Kulke⁴³, Steven Lamberts, van Nieveen⁴⁴, Juan O'Connor⁴⁵, Dermot O'Toole⁴⁶, Ulrich-Frank Pape⁴⁷, Stefano Partelli⁴⁸, Marianne Pavel⁴⁹, Marc Peeters⁵⁰, John Ramage⁵¹, Nicholas Reed⁵², Guido Rindi⁵³, Anja Rinke⁵⁴, Philippe Ruszniewski⁵⁵, Halfdan Sorbye⁵⁶, Anders Sundin⁵⁷, Jean-Yves Scoazec⁵⁸, Babs Taal⁵⁹, Janson Tiensuu⁶⁰, Christos Toumpanakis³⁴, Juan Valle⁶¹, Marie-Pierre Vullierme⁶², Staffan Welin⁶³, Bertram Wiedenmann⁶⁴

Affiliations

¹ Cell Biology Section, NIDDK, National Institutes of Health, Bethesda, Maryland, [email protected].
² Memorial Sloan Kettering Cancer Center, New York, New York, USA.
³ Department of Medical Oncology, Vall d'Hebron University Hospital, Vall Hebron Institute of Oncology, Universitat Autònoma de Barcelona, Barcelona, Spain.
⁴ Service de Pathologie, Hôpital Bichat, Paris, France.
⁵ Chirurgia del Pancreas, Università Vita e Salute, San Raffaele Hospital IRCCS, Milan, Italy.
⁶ Neuroendocrine Unit, Endocrinology and Metabolism Service, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.
⁷ Institute of Pathology, Technische Universität München, Munich, Germany.
⁸ Department of Internal Medicine, Division of Endocrinology, Erasmus Medical Center, Rotterdam, The Netherlands.
⁹ Department of Oncology, Antwerp University Hospital, Edegem, Belgium.
¹⁰ Institute of Anatomic Pathology, Policlinico A. Gemelli, Università Cattolica del Sacro Cuore, Rome, Italy.
¹¹ Department of Gastroenterology, UKGM Marburg and Philipps University, Marburg, Germany.
¹² Department of Surgery, Philipps University, Marburg, Germany.
¹³ Department of Radiology, Institute of Surgical Sciences, Uppsala University, Uppsala, Sweden.
¹⁴ Endocrine Oncology Unit, Department of Medical Sciences, University Hospital, Uppsala, Sweden.
¹⁵ Gastrointestinal and Neuroendocrine Oncology Unit, European Institute of Oncology (IEO), Milan, Italy.
¹⁶ UKGM GmbH, Marburg, Germany.
¹⁷ University Hospital, Marburg, Germany.
¹⁸ Institut Gustave, Roussy, France.
¹⁹ Memorial Sloan Kettering Cancer Center, USA.
²⁰ Cliniques universitaires, Saint-Luc, Belgium.
²¹ Vall d'Hebron University Hospital, Vall Hebron Institute of Oncology (VHIO), Spain.
²² Department of Medicine, Royal Free Hospital, UK.
²³ The First Affiliated Hospital, Sun Yat-Sen University, China.
²⁴ Oncoclin Medicos Associados S/S Ltda. c/o Frederico Costa - Regina Lima, Brazil.
²⁵ Hôpital Bichat, Service de Pathologie, France.
²⁶ Department of Radiology, Faculty of Medical Sciences, Univeristy of Warmia and Mazury, Poland.
²⁷ Erasmus MC, Department of Internal Medicine, Section of Endocrinology, The Netherlands.
²⁸ Department of Surgery, Università Vita e Salute, Italy.
²⁹ Department of Endocrine Oncology, Uppsala University Hospital, Sweden.
³⁰ European Institute of Oncology, Italy.
³¹ University of Genova, Italy.
³² Department of Surgery and Cancer, Imperial College London, Hammersmith Hospital, UK.
³³ Hospital Universitario Doce de Octubre, Spain.
³⁴ Royal Free Hospital, London, UK.
³⁵ Zentralklinik Bad Berka GmbH, CA Gastroenterologie, Germany.
³⁶ National Institutes of Health, USA.
³⁷ Endocrine Unit, Department of Pathophysiology, National University of Athens, Greece.
³⁸ Consultation Center for Pancreatic and Endocrine Tumors/Department of Pathology/TU-Munich, Germany.
³⁹ Rigshospitalet, Department of Surgery (C2122), Denmark.
⁴⁰ Department of Endocrinology and Neuroendocrine Tumors, Medical University of Silesia, Poland.
⁴¹ Universitätsklinik für Innere Medizin, Austria.
⁴² Erasmus MC, The Netherlands.
⁴³ Dana-Farber Cancer Institute, USA.
⁴⁴ Amsterdam Working Hospital, The Netherlands.
⁴⁵ Instituto Fleming, Argentina.
⁴⁶ St. James's and St Vincnt's Univerrsity Hospitals and Trinity College Dublin, Ireland.
⁴⁷ Charité Campus Mitte, Berlin, Germany.
⁴⁸ Pancreatic Surgery Unit, Pancreas Translational and Clinical Research Center, San Raffaele Scientific Institute, "Vita-Salute" University, Milan, Italy.
⁴⁹ Universitätsklinikum Erlangen, Germany.
⁵⁰ Department of Oncology, Antwerp University Hospital, Belgium.
⁵¹ Hampshire Hospitals NHS Trust, UK.
⁵² Beatson Oncology Centre/Gartnavel General Hospital, UK.
⁵³ Policlinico Universitario A. Gemelli, Rome, Italy.
⁵⁴ Uniklinikum Giessen und Marburg, Germany.
⁵⁵ Department of Gastroenterology-Pancreatology, Beaujon Hospital, France.
⁵⁶ Haukeland University Hospital, Department of Oncology, Norway.
⁵⁷ Department of Radiology, Institute of Surgical Sciences, Uppsala University, Akademiska Sjukhuset, Uppsala, Sweden.
⁵⁸ Gustave Roussy, Biopathology, France.
⁵⁹ Netherlands Cancer Centre, The Netherlands.
⁶⁰ Uppsala University, Sweden.
⁶¹ University of Manchester/The Christie NHS Foundation Trust, UK.
⁶² Hôpital Beaujon - Radiologie, France.
⁶³ Endocrine Oncology, University Hospital, Uppsala, Sweden.
⁶⁴ Gastroenterology, Charité Medical School and Hospital (Virchow), Germany.

PMID: 30282083
DOI: 10.1159/000494258

Abstract

Recently, the European Neuroendocrine Tumor Society (ENETS) held working sessions composed of members of the advisory board and other neuroendocrine neoplasm (NEN) experts to attempt to identify unmet needs in NENs in different locations or with advanced/poorly differentiated NENs. This report briefly summarizes the main proposed areas of unmet needs in patients with functional and nonfunctional pancreatic NENs.

Publication types

Review

MeSH terms

Biomarkers, Tumor / metabolism
Biomedical Research / trends*
Disease Management*
Humans
Neuroendocrine Tumors* / diagnosis
Neuroendocrine Tumors* / drug therapy
Neuroendocrine Tumors* / metabolism
Pancreatic Neoplasms* / diagnosis
Pancreatic Neoplasms* / drug therapy
Pancreatic Neoplasms* / metabolism
Prognosis

Substances

Biomarkers, Tumor