Gutting TMA to Save the Heart

Cell Host Microbe. 2018 Oct 10;24(4):470-471. doi: 10.1016/j.chom.2018.09.014.

Abstract

Microbial activities of gut commensals have been linked to several host diseases. In recent work, Roberts et al. (2018) develop therapeutics targeting microbial production of the metabolite trimethylamine (TMA), which has been linked to cardiovascular disease. This microbiota-based approach holds promise for efficacious therapies that may also reduce host side effects.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cardiovascular Diseases / prevention & control*
  • Choline / metabolism
  • Diet
  • Gastrointestinal Microbiome / physiology*
  • Gastrointestinal Tract / microbiology*
  • Host Microbial Interactions
  • Humans
  • Methylamines / metabolism*
  • Mice
  • Mice, Knockout

Substances

  • Methylamines
  • trimethylamine
  • Choline