Compositional and Temporal Changes in the Gut Microbiome of Pediatric Ulcerative Colitis Patients Are Linked to Disease Course

Affiliations

• ¹ The Broad Institute of MIT and Harvard, Infectious Disease and Microbiome, Cambridge, MA 02142, USA; Harvard T.H. Chan School of Public Health, Biostatistics Department, Boston, MA 02115, USA.
• ² Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
• ³ The Broad Institute of MIT and Harvard, Infectious Disease and Microbiome, Cambridge, MA 02142, USA; Center for Microbiome Informatics and Therapeutics, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA.
• ⁴ Collaborative Studies Coordinating Center, Department of Biostatistics, University of North Carolina, Chapel Hill, NC 27516, USA; RTI International, Biostatistics and Epidemiology Division, Research Triangle Park, NC 27709, USA.
• ⁵ Collaborative Studies Coordinating Center, Department of Biostatistics, University of North Carolina, Chapel Hill, NC 27516, USA.
• ⁶ Children's Hospital Boston, Boston, MA 02115, USA.
• ⁷ Women and Children's Hospital of Buffalo WCHOB, Buffalo, NY 14222, USA.
• ⁸ Emory Children's Center, Atlanta, GA 30322, USA.
• ⁹ Cohen Children's Medical Center, Pediatric Gastroenterology, New York, NY 11040, USA.
• ¹⁰ Riley Children's Hospital Indiana University, School of Medicine, Section of Gastroenterology/Hepatology/Nutrition, Indianapolis, IN 46202, USA.
• ¹¹ Johns Hopkins Children's Center, Department of Pediatrics, Baltimore, MD 21287, USA.
• ¹² Goryeb Children's Hospital/Atlantic Health, Pediatric Gastroenterology, Morristown, NJ 07960, USA.
• ¹³ IWK Health Centre, Division of Gastroenterology and Nutrition, Halifax, NS B3K 6R8, Canada.
• ¹⁴ Nationwide Children's Hospital, Pediatrics, Columbus, OH 43205, USA.
• ¹⁵ Children's Hospital of Eastern Ontario and University of Ottawa, Department of Pediatrics, Ottawa, ON K1H 8L1, Canada.
• ¹⁶ Children's Hospital of Philadelphia CHOP, Pediatric Gastroenterologist, Philadelphia, PA 19104, USA.
• ¹⁷ UPMC Children's Hospital of Pittsburgh, Department of Pediatrics, Pittsburgh, PA 15224, USA.
• ¹⁸ Hasbro Children's Hospital, Pediatric Gastroenterology, Providence, RI 02903, USA.
• ¹⁹ University of California at San Francisco, Pediatric Gastroenterology, San Francisco, CA 94158, USA.
• ²⁰ Sickkids Hospital, University of Toronto, Gastroenterology, Hepatology and Nutrition, Toronto, ON M5G 1X8, Canada.
• ²¹ UT Southwestern, Department of Pediatrics, Dallas, TX 75390, USA.
• ²² Medical College of Wisconsin, Gastroenterology, Milwaukee, WI 53226, USA.
• ²³ Connecticut Children's Medical Center, Division of Digestive Diseases, Hartford, CT 06106, USA.
• ²⁴ The Broad Institute of MIT and Harvard, Infectious Disease and Microbiome, Cambridge, MA 02142, USA; Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, MA 02114, USA; Gastrointestinal Unit and Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital, Boston, MA 02114, USA; Center for Microbiome Informatics and Therapeutics, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA. Electronic address: [email protected].