Targeted next generation sequencing reveals high mutation frequency of CREBBP, BCL2 and KMT2D in high-grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements

Haematologica. 2019 Apr;104(4):e154-e157. doi: 10.3324/haematol.2018.198572. Epub 2018 Oct 11.
No abstract available

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • CREB-Binding Protein / genetics*
  • DNA-Binding Proteins / genetics*
  • Female
  • Gene Rearrangement*
  • High-Throughput Nucleotide Sequencing*
  • Humans
  • Lymphoma, B-Cell / genetics*
  • Male
  • Middle Aged
  • Mutation*
  • Neoplasm Proteins / genetics*
  • Proto-Oncogene Proteins c-bcl-2 / genetics*
  • Proto-Oncogene Proteins c-bcl-6 / genetics*
  • Proto-Oncogene Proteins c-myc / genetics*

Substances

  • BCL2 protein, human
  • BCL6 protein, human
  • DNA-Binding Proteins
  • KMT2D protein, human
  • MYC protein, human
  • Neoplasm Proteins
  • Proto-Oncogene Proteins c-bcl-2
  • Proto-Oncogene Proteins c-bcl-6
  • Proto-Oncogene Proteins c-myc
  • CREB-Binding Protein
  • CREBBP protein, human