The Importance of mTOR Trafficking for Human Skeletal Muscle Translational Control

Nathan Hodson; Andrew Philp

doi:10.1249/JES.0000000000000173

The Importance of mTOR Trafficking for Human Skeletal Muscle Translational Control

Exerc Sport Sci Rev. 2019 Jan;47(1):46-53. doi: 10.1249/JES.0000000000000173.

Authors

Nathan Hodson¹, Andrew Philp^{1

2}

Affiliations

¹ School of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, Birmingham, UK.
² Garvan Institute of Medical Research, Darlinghurst, Sydney, New South Wales, Australia.

Abstract

The mechanistic target of rapamycin (mTOR) is a central regulator of muscle protein synthesis, and its activation has long been attributed to its translocation to the lysosome. Here, we present a novel model of mTOR activation in skeletal muscle where the translocation of mTOR and the lysosome toward the cell membrane is a key process in mTOR activation.

Publication types

Review

MeSH terms

Humans
Lysosomes / metabolism*
Mechanistic Target of Rapamycin Complex 1 / metabolism
Muscle Proteins / biosynthesis*
Muscle, Skeletal / metabolism*
Protein Transport
Resistance Training
TOR Serine-Threonine Kinases / metabolism*

Substances

Muscle Proteins
MTOR protein, human
Mechanistic Target of Rapamycin Complex 1
TOR Serine-Threonine Kinases