Norditerpenoid alkaloids from Delphinium pseudoaemulans C. Y. Yang et B. Wang

Wen-Juan Xue; Bo Zhao; Zukela Ruzi; Jiang-Yu Zhao; Haji Akber Aisa

doi:10.1016/j.phytochem.2018.09.010

Norditerpenoid alkaloids from Delphinium pseudoaemulans C. Y. Yang et B. Wang

Phytochemistry. 2018 Dec:156:234-240. doi: 10.1016/j.phytochem.2018.09.010. Epub 2018 Oct 16.

Authors

Wen-Juan Xue¹, Bo Zhao², Zukela Ruzi³, Jiang-Yu Zhao², Haji Akber Aisa⁴

Affiliations

¹ The Key Laboratory of Plant Resources and Chemistry of Arid Zone, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi, 830011, PR China; University of Chinese Academy of Sciences, Beijing, 100039, PR China.
² The Key Laboratory of Plant Resources and Chemistry of Arid Zone, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi, 830011, PR China; State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi, 830011, PR China.
³ State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi, 830011, PR China; University of Chinese Academy of Sciences, Beijing, 100039, PR China.
⁴ The Key Laboratory of Plant Resources and Chemistry of Arid Zone, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi, 830011, PR China; State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi, 830011, PR China. Electronic address: [email protected].

PMID: 30340117
DOI: 10.1016/j.phytochem.2018.09.010

Abstract

Eight previously undescribed norditerpenoid alkaloids, pseudophnines A-D, pseudorenines A-B, and pseudonidines A-B, together with ten known norditerpenoid alkaloids, tianshanisine E, sharwuphinine B, potanisine A, lycoctonine, delbruline, isondelpheline, delavaines A-B, and shawurenines A-B were isolated from the whole plant of Delphinium pseudoaemulans C. Y. Yang et B. Wang. Their structures were established on the basis of spectroscopic analyses, including HR-ESI-MS, 1D and 2D NMR analysis. Additionally, no cytotoxicity was observed against A549 and HeLa cancer cells of these diterpenoid alkaloids when evaluated in vitro using the MTT method.

Keywords: Cytotoxicity; Delphinium pseudoaemulans C. Y. Yang et B. Wang; Diterpenoid alkaloids; Pseudonidine; Pseudophnine; Pseudorenine; Ranunculaceae.

MeSH terms

Alkaloids / chemistry
Alkaloids / isolation & purification*
Delphinium / chemistry*
Diterpenes / chemistry
Diterpenes / isolation & purification*
HeLa Cells
Humans
Molecular Structure
Tumor Cells, Cultured

Substances

Alkaloids
Diterpenes