SEMA4A promotes eosinophil survival and contributes to eosinophil-mediated allergic diseases

Yohei Maeda; Takeshi Tsuda; Yoshito Takeda; Shohei Koyama; Yoshitomo Hayama; Satoshi Nojima; Tetsuya Kimura; Daisuke Ito; Hyota Takamatsu; Sujin Kang; Masayuki Nishide; Keiko Morimoto; Takashi Hosokawa; Yuhei Kinehara; Yasuhiro Kato; Takeshi Nakatani; Kazuya Takeda; Masaki Hayama; Sho Obata; Hitoshi Akazawa; Takashi Shikina; Hidenori Inohara; Atsushi Kumanogoh

doi:10.1016/j.alit.2018.10.001

SEMA4A promotes eosinophil survival and contributes to eosinophil-mediated allergic diseases

Allergol Int. 2019 Apr;68(2):274-276. doi: 10.1016/j.alit.2018.10.001. Epub 2018 Oct 19.

Authors

Yohei Maeda¹, Takeshi Tsuda¹, Yoshito Takeda², Shohei Koyama³, Yoshitomo Hayama⁴, Satoshi Nojima⁵, Tetsuya Kimura⁶, Daisuke Ito⁴, Hyota Takamatsu⁴, Sujin Kang⁷, Masayuki Nishide⁴, Keiko Morimoto⁸, Takashi Hosokawa⁴, Yuhei Kinehara⁴, Yasuhiro Kato⁴, Takeshi Nakatani⁴, Kazuya Takeda⁹, Masaki Hayama⁹, Sho Obata⁹, Hitoshi Akazawa¹⁰, Takashi Shikina¹⁰, Hidenori Inohara⁹, Atsushi Kumanogoh⁴

Affiliations

¹ Department of Otorhinolaryngology-Head and Neck Surgery, Osaka University Graduate School of Medicine, Osaka, Japan; Department of Respiratory Medicine, Allergy and Rheumatic Diseases, Osaka University Graduate School of Medicine, Osaka, Japan; Laboratory of Immunopathology, World Premier International Immunology Frontier Research Center, Osaka, Japan; Integrated Frontier Research for Medical Science Division, The Institute for Open and Transdisciplinary Research Initiatives (OTRI), Osaka, Japan.
² Department of Respiratory Medicine, Allergy and Rheumatic Diseases, Osaka University Graduate School of Medicine, Osaka, Japan. Electronic address: [email protected].
³ Department of Respiratory Medicine, Allergy and Rheumatic Diseases, Osaka University Graduate School of Medicine, Osaka, Japan; Laboratory of Immunopathology, World Premier International Immunology Frontier Research Center, Osaka, Japan; Integrated Frontier Research for Medical Science Division, The Institute for Open and Transdisciplinary Research Initiatives (OTRI), Osaka, Japan. Electronic address: [email protected].
⁴ Department of Respiratory Medicine, Allergy and Rheumatic Diseases, Osaka University Graduate School of Medicine, Osaka, Japan; Laboratory of Immunopathology, World Premier International Immunology Frontier Research Center, Osaka, Japan; Integrated Frontier Research for Medical Science Division, The Institute for Open and Transdisciplinary Research Initiatives (OTRI), Osaka, Japan.
⁵ Department of Respiratory Medicine, Allergy and Rheumatic Diseases, Osaka University Graduate School of Medicine, Osaka, Japan; Laboratory of Immunopathology, World Premier International Immunology Frontier Research Center, Osaka, Japan; Integrated Frontier Research for Medical Science Division, The Institute for Open and Transdisciplinary Research Initiatives (OTRI), Osaka, Japan; Department of Pathology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.
⁶ Department of Respiratory Medicine, Allergy and Rheumatic Diseases, Osaka University Graduate School of Medicine, Osaka, Japan; Laboratory of Immunopathology, World Premier International Immunology Frontier Research Center, Osaka, Japan; Integrated Frontier Research for Medical Science Division, The Institute for Open and Transdisciplinary Research Initiatives (OTRI), Osaka, Japan; Department of Oncogene Research, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan.
⁷ Department of Respiratory Medicine, Allergy and Rheumatic Diseases, Osaka University Graduate School of Medicine, Osaka, Japan; Laboratory of Immunopathology, World Premier International Immunology Frontier Research Center, Osaka, Japan; Integrated Frontier Research for Medical Science Division, The Institute for Open and Transdisciplinary Research Initiatives (OTRI), Osaka, Japan; Department of Immune Regulation, Immunology Frontier Research Center, Osaka University, Osaka, Japan.
⁸ Department of Respiratory Medicine, Allergy and Rheumatic Diseases, Osaka University Graduate School of Medicine, Osaka, Japan; Laboratory of Immunopathology, World Premier International Immunology Frontier Research Center, Osaka, Japan; Integrated Frontier Research for Medical Science Division, The Institute for Open and Transdisciplinary Research Initiatives (OTRI), Osaka, Japan; Department of Anatomy, Keio University School of Medicine, Tokyo, Japan.
⁹ Department of Otorhinolaryngology-Head and Neck Surgery, Osaka University Graduate School of Medicine, Osaka, Japan.
¹⁰ Department of Otorhinolaryngology-Head and Neck Surgery, Osaka University Graduate School of Medicine, Osaka, Japan; Department of Otolaryngology, Ikeda Municipal Hospital, Osaka, Japan.

PMID: 30342889
DOI: 10.1016/j.alit.2018.10.001

No abstract available

Publication types

Letter

MeSH terms

ADAMTS4 Protein / immunology
Cell Survival
Eosinophils / immunology*
Humans
Hypersensitivity / blood*
Hypersensitivity / immunology*
Semaphorins / blood*

Substances

SEMA4A protein, human
Semaphorins
ADAMTS4 Protein
ADAMTS4 protein, human