Apolipoprotein A-IV: A potential therapeutic target for atherosclerosis

Prostaglandins Other Lipid Mediat. 2018 Nov:139:87-92. doi: 10.1016/j.prostaglandins.2018.10.004. Epub 2018 Oct 22.

Abstract

Apolipoprotein A-IV is lipid-binding protein, which is synthesized by the intestine and secreted into mesenteric lymph. ApoA-IV is correlated with chylomicrons and high density lipoprotein, but a large portion is free-lipoprotein, in circulation. Studies showed that apoA-IV has anti-inflammatory and anti-oxidative properties, and is able to mediate reverse cholesterol transport, which suggest that it may has anti-atherosclerotic effects and be related to protection from atherosclerotic cardiovascular disease. This article focus on current studies and the possible anti-atherogenic mechanism related to apoA-IV, in order to provide a new therapeutic target for atherosclerotic cardiovascular diseases.

Keywords: Apolipoprotein A-IV; Atherosclerosis; Lipids; Mechanism.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Apolipoproteins A / genetics
  • Apolipoproteins A / metabolism*
  • Atherosclerosis / genetics
  • Atherosclerosis / metabolism*
  • Atherosclerosis / pathology
  • Cholesterol
  • Humans
  • Intestinal Mucosa / metabolism
  • Lipid Metabolism / genetics*
  • Lipoproteins, HDL / genetics
  • Lipoproteins, HDL / metabolism
  • Protein Binding / genetics
  • Protein Transport / genetics*

Substances

  • Apolipoproteins A
  • Lipoproteins, HDL
  • apolipoprotein A-IV
  • Cholesterol