Abstract
Noradrenaline enhanced in a concentration-dependent way the basal release of endogenous GABA from superfused rat hippocampus synaptosomes. The alpha 2-adrenoceptor antagonist yohimbine prevented the releasing effect of noradrenaline while the alpha 1-adrenoceptor antagonist prazosin was ineffective. It is concluded that GABAergic nerve terminals in rat hippocampus possess adrenoceptors of the alpha 2-subtype whose activation causes enhancement of GABA release.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Hippocampus / drug effects
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Hippocampus / metabolism*
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Male
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Nerve Endings / drug effects
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Nerve Endings / metabolism
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Norepinephrine / physiology*
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Prazosin / pharmacology
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Rats
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Rats, Inbred Strains
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Receptors, Adrenergic, alpha / drug effects
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Receptors, Adrenergic, alpha / metabolism
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Synaptosomes / drug effects
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Synaptosomes / metabolism
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Yohimbine / pharmacology
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gamma-Aminobutyric Acid / metabolism*
Substances
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Receptors, Adrenergic, alpha
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Yohimbine
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gamma-Aminobutyric Acid
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Norepinephrine
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Prazosin