Biological macromolecule delivery system fabricated using zein and gum arabic to control the release rate of encapsulated tocopherol during in vitro digestion

Food Res Int. 2018 Dec:114:251-257. doi: 10.1016/j.foodres.2018.08.073. Epub 2018 Aug 24.

Abstract

Nanoparticles were fabricated by adsorbing gum arabic (GA) on zein nanoparticles by antisolvent precipitation. The most stable mass ratio of zein:GA was 1:1.5 with a stable zeta-potential (-32.8 mV) in a pH range of 3.0-9.0. The surface hydrophobicity of zein-GA nanoparticles indicated formation of a stable structure through electrostatic attraction at a pH range of 3.0-6.0 and hydrophobic interaction at pH 7.0-9.0. The FTIR spectrogram showed an additional role of hydrogen bonds to promote the adsorption of GA on zein nanoparticles. Tocopherol (TOC) was encapsulated within the prepared zein-GA nanoparticles with a high loading capacity. The presence of GA not only prevented the precipitation of zein nanoparticles but also controlled the release of TOC from zein-GA nanoparticles during in vitro gastrointestinal digestion. Zein-GA biopolymer nanoparticles can be stably fabricated in a wide pH range for applications in the food and pharmacy industries.

Keywords: Delivery systems; Gum arabic; Nanoparticles; Release; Tocopherol; Zein.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Digestion
  • Drug Compounding
  • Gum Arabic / chemistry*
  • Humans
  • Models, Biological
  • Nanoparticles / chemistry*
  • Particle Size
  • Tocopherols* / chemistry
  • Tocopherols* / pharmacokinetics
  • Zein / chemistry*

Substances

  • Gum Arabic
  • Zein
  • Tocopherols