Large Paraesophageal Schwannoma With Intense Prostate-Specific Membrane Antigen Expression on 68Ga-PSMA-PET/CT Mimicking Lymph Node Metastasis in a Patient With Prostate Cancer

Clin Nucl Med. 2019 Feb;44(2):153-154. doi: 10.1097/RLU.0000000000002359.

Abstract

Prostate-specific membrane antigen (PSMA)-PET/CT as an emerging modality in molecular imaging will lead to earlier detection and localization of relapse in prostate cancer but will undoubtedly also lead to false-positive findings, as it becomes clear that this new tracer is not as specific as its name would suggest. In this context, we present a case of a large PSMA-expressing schwannoma, a rare nerve sheath tumor mimicking paraesophageal lymph node metastasis in a patient with a history of prostate cancer and biochemical recurrence.

Publication types

  • Case Reports

MeSH terms

  • Antigens, Surface / metabolism*
  • Diagnosis, Differential
  • Edetic Acid / analogs & derivatives*
  • Esophageal Neoplasms / diagnostic imaging*
  • Esophageal Neoplasms / metabolism
  • Esophageal Neoplasms / pathology
  • Gallium Isotopes
  • Gallium Radioisotopes
  • Gene Expression Regulation, Neoplastic*
  • Glutamate Carboxypeptidase II / metabolism*
  • Humans
  • Lymphatic Metastasis
  • Male
  • Middle Aged
  • Neurilemmoma / diagnostic imaging*
  • Neurilemmoma / metabolism
  • Neurilemmoma / pathology
  • Oligopeptides*
  • Positron Emission Tomography Computed Tomography*
  • Prostatic Neoplasms / pathology*
  • Recurrence

Substances

  • Antigens, Surface
  • Gallium Isotopes
  • Gallium Radioisotopes
  • Oligopeptides
  • gallium 68 PSMA-11
  • Edetic Acid
  • FOLH1 protein, human
  • Glutamate Carboxypeptidase II