RETRACTED: LEF-1 gene silencing inhibits pulmonary vascular remodeling and occurrence of pulmonary arterial hypertension through the β-catenin signaling pathway

Biomed Pharmacother. 2018 Dec:108:817-827. doi: 10.1016/j.biopha.2018.08.118. Epub 2018 Sep 24.

Abstract

This article has been retracted: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our-business/policies/article-withdrawal). This article has been retracted at the request of the authors as the validity of the pulmonary vascular remodeling indicators cannot be guaranteed. The authors tried post publication to reproduce the results of the cell proliferation and cell aging, however they were not able to confirm the data that was presented by the article.

Keywords: Gene silencing; LEF-1; Pulmonary arterial hypertension; Pulmonary vascular remodeling; β-catenin signaling pathway.

Publication types

  • Retracted Publication

MeSH terms

  • Animals
  • Apoptosis / genetics
  • Caspase 3 / genetics
  • Cell Proliferation / genetics
  • Gene Silencing / physiology*
  • Glycogen Synthase Kinase 3 beta / genetics
  • Hypertension, Pulmonary / genetics
  • Inhibitor of Apoptosis Proteins / genetics
  • Lung / physiology*
  • Lymphoid Enhancer-Binding Factor 1 / genetics*
  • Male
  • Pulmonary Artery / physiology*
  • Rats
  • Rats, Sprague-Dawley
  • Signal Transduction / genetics*
  • Vascular Remodeling / genetics*
  • beta Catenin / genetics*

Substances

  • Inhibitor of Apoptosis Proteins
  • Lymphoid Enhancer-Binding Factor 1
  • beta Catenin
  • Glycogen Synthase Kinase 3 beta
  • Caspase 3