Convenient synthesis of novel macrocyclic urethanes: alkoxycarbonylation of amines and ring-closing metathesis strategy

Tetrahedron Lett. 1998 Apr 2;39(14):1881-1884. doi: 10.1016/S0040-4039(98)00153-1.

Abstract

Alkoxycarbonylation of amines followed by ring-closing metathesis of the resulting dienes with Grubbs catalyst (25-50 mol%) provided convenient access to 14-16 membered macrocyclic urethanes in very good yields. 0 1998 Elsevier Science Ltd. All rights reserved.