Bottom-up approach to torus bifurcation in neuron models

Chaos. 2018 Oct;28(10):106317. doi: 10.1063/1.5042078.

Abstract

We study the quasi-periodicity phenomena occurring at the transition between tonic spiking and bursting activities in exemplary biologically plausible Hodgkin-Huxley type models of individual cells and reduced phenomenological models with slow and fast dynamics. Using the geometric slow-fast dissection and the parameter continuation approach, we show that the transition is due to either the torus bifurcation or the period-doubling bifurcation of a stable periodic orbit on the 2D slow-motion manifold near a characteristic fold. Various torus bifurcations including stable and saddle torus-canards, resonant tori, the co-existence of nested tori, and the torus breakdown leading to the onset of complex and bistable dynamics in such systems are examined too.

MeSH terms

  • Action Potentials / physiology
  • Animals
  • Biological Clocks / physiology
  • Calcium / physiology
  • Cations
  • Computer Simulation
  • Humans
  • Models, Neurological
  • Neurons / physiology*
  • Nonlinear Dynamics
  • Oscillometry
  • Purkinje Cells / physiology
  • Pyramidal Cells / physiology
  • Rana catesbeiana
  • Saccule and Utricle / physiology

Substances

  • Cations
  • Calcium