20 Years of Human Pluripotent Stem Cell Research: It All Started with Five Lines

Tenneille E Ludwig; Angela Kujak; Antonio Rauti; Steven Andrzejewski; Susan Langbehn; James Mayfield; Jacqueline Fuller; Yoshimi Yashiro; Yasushi Hara; Anita Bhattacharyya

doi:10.1016/j.stem.2018.10.009

20 Years of Human Pluripotent Stem Cell Research: It All Started with Five Lines

Cell Stem Cell. 2018 Nov 1;23(5):644-648. doi: 10.1016/j.stem.2018.10.009.

Affiliations

¹ WiCell Research Institute, Madison, WI, USA; Office of the Vice Chancellor for Research and Graduate Education, University of Wisconsin-Madison, Madison, WI, USA. Electronic address: [email protected].
² Wisconsin Alumni Research Foundation, Madison, WI, USA.
³ Kanagawa University of Human Services, Kanagawa, Japan.
⁴ Centre for French-Japanese Advanced Studies in Paris (CEAFJP), Fondation France-Japon de l'EHESS, Paris, France.
⁵ Waisman Center, Cell and Regenerative Biology, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA.

PMID: 30388422
DOI: 10.1016/j.stem.2018.10.009

Abstract

November 2018 marks the 20^th anniversary of the seminal human embryonic stem cell (hESC) publication, which reported the initial hESC derivations and launched the field of human pluripotent stem cell research. To commemorate this significant milestone, we reflect on the scientific, economic, and clinically relevant impact of this groundbreaking achievement.

Publication types

Historical Article
Research Support, Non-U.S. Gov't

MeSH terms

Cell Line
History, 20th Century
History, 21st Century
Humans
Pluripotent Stem Cells / cytology*
Stem Cell Research / history*