MEK Inhibitor Reverses Metaplasia and Allows Re-Emergence of Normal Lineages in Helicobacter pylori-Infected Gerbils

Gastroenterology. 2019 Feb;156(3):577-581.e4. doi: 10.1053/j.gastro.2018.10.049. Epub 2018 Nov 2.
No abstract available

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Acrylonitrile / administration & dosage
  • Acrylonitrile / analogs & derivatives*
  • Aniline Compounds / administration & dosage*
  • Animals
  • Benzimidazoles / administration & dosage*
  • Biopsy, Needle
  • Disease Models, Animal
  • Gastric Mucosa / drug effects
  • Gastric Mucosa / microbiology
  • Gastric Mucosa / pathology*
  • Gerbillinae
  • Helicobacter Infections / drug therapy*
  • Helicobacter Infections / pathology*
  • Helicobacter pylori / drug effects
  • Immunohistochemistry
  • Male
  • Metaplasia / drug therapy
  • Metaplasia / prevention & control
  • Random Allocation
  • Reference Values
  • Treatment Outcome

Substances

  • AZD 6244
  • Aniline Compounds
  • Benzimidazoles
  • MEK inhibitor I
  • Acrylonitrile