A Convenient Enzymatic Route to Optically Active l-Aminoindan-2-ol: Versatile Ligands for HIV-1 Protease Inhibitors and Asymmetric Syntheses

Arun K Ghosh; John F Kincaid; Michael G Haske

doi:10.1055/s-1997-1235

A Convenient Enzymatic Route to Optically Active l-Aminoindan-2-ol: Versatile Ligands for HIV-1 Protease Inhibitors and Asymmetric Syntheses

Synthesis (Stuttg). 1997 May;1997(5):541-544. doi: 10.1055/s-1997-1235.

Authors

Arun K Ghosh¹, John F Kincaid¹, Michael G Haske¹

Affiliation

¹ Department of Chemistry, University of Illinois at Chicago, 845 West Taylor Street, Chicago, Illinois 60607, USA.

Abstract

(1S,2R)- and (1R,2S)-l-aminoindan-2-ol were prepared in high enantiomeric excess (>96%) by an immobilized lipase-catalyzed selective acylation of racemic trans- l-azidoindan-2-ol.

Abstract

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