Abstract
Purpurolide A (1), an unprecedent sesquiterpene lactone with a rarely encountered 5/5/5 spirocyclic skeleton, along with two new 6/4/5/5 tetracyclic sesquiterpene lactones (2 and 3), were isolated from the cultures of the endophytic fungus Penicillium purpurogenum IMM003. The structures and absolute configurations of 1-3 were established by spectroscopic analysis, single-crystal X-ray diffraction, and calculations of the 13C NMR and ECD data. Compounds 1-3 showed significant inhibitory activity against pancreatic lipase.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Enzyme Inhibitors / chemistry
-
Enzyme Inhibitors / isolation & purification*
-
Enzyme Inhibitors / pharmacology
-
Lactones / chemistry
-
Lactones / isolation & purification*
-
Lactones / pharmacology
-
Lipase / antagonists & inhibitors
-
Molecular Structure
-
Penicillium / isolation & purification
-
Penicillium / metabolism*
-
Plant Leaves / microbiology
-
Sesquiterpenes / chemistry
-
Sesquiterpenes / isolation & purification*
-
Sesquiterpenes / pharmacology
-
Spiro Compounds / chemistry
-
Spiro Compounds / isolation & purification*
-
Spiro Compounds / pharmacology
-
Stereoisomerism
-
Thymelaeaceae / microbiology
Substances
-
Enzyme Inhibitors
-
Lactones
-
Sesquiterpenes
-
Spiro Compounds
-
Lipase