Insulin-Like Growth Factor Binding Protein 2 (IGFBP-2) and the Risk of Developing Type 2 Diabetes

Clemens Wittenbecher; Meriem Ouni; Olga Kuxhaus; Markus Jähnert; Pascal Gottmann; Andrea Teichmann; Karina Meidtner; Jennifer Kriebel; Harald Grallert; Tobias Pischon; Heiner Boeing; Matthias B Schulze; Annette Schürmann

doi:10.2337/db18-0620

Insulin-Like Growth Factor Binding Protein 2 (IGFBP-2) and the Risk of Developing Type 2 Diabetes

Diabetes. 2019 Jan;68(1):188-197. doi: 10.2337/db18-0620. Epub 2018 Nov 5.

Authors

Clemens Wittenbecher^{1

2}, Meriem Ouni^{2

3}, Olga Kuxhaus^{1

2}, Markus Jähnert^{2

3}, Pascal Gottmann^{2

3}, Andrea Teichmann^{2

3}, Karina Meidtner¹, Jennifer Kriebel^{2

4}, Harald Grallert^{2

4}, Tobias Pischon^{5

6

7

8}, Heiner Boeing⁹, Matthias B Schulze^{1

2

10}, Annette Schürmann^{11

3}

Affiliations

¹ Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbrücke, Nuthetal, Germany.
² German Center for Diabetes Research (DZD), München-Neuherberg, Germany.
³ Department of Experimental Diabetology, German Institute of Human Nutrition Potsdam-Rehbrücke, Nuthetal, Germany.
⁴ Research Unit of Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München German Research Center for Environmental Health, Neuherberg, Germany.
⁵ Molecular Epidemiology Research Group, Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany.
⁶ Charité-Universitätsmedizin Berlin, Berlin, Germany.
⁷ Deutsches Zentrum für Herz-Kreislaufforschung e.V., partner site Berlin, Berlin, Germany.
⁸ Max Delbrück Center for Molecular Medicine and Berlin Institute of Health Biobank, Berlin, Germany.
⁹ Department of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbrücke, Nuthetal, Germany.
¹⁰ Institute of Nutritional Sciences, University of Potsdam, Nuthetal, Germany.
¹¹ German Center for Diabetes Research (DZD), München-Neuherberg, Germany [email protected].

PMID: 30396904
DOI: 10.2337/db18-0620

Abstract

Recent studies suggest that insulin-like growth factor binding protein 2 (IGFBP-2) may protect against type 2 diabetes, but population-based human studies are scarce. We aimed to investigate the prospective association of circulating IGFBP-2 concentrations and of differential methylation in the IGFBP-2 gene with type 2 diabetes risk.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Aged
Blood Glucose / metabolism
DNA Methylation / physiology
Diabetes Mellitus, Type 2 / blood*
Female
Humans
Insulin-Like Growth Factor Binding Protein 2 / blood*
Male
Middle Aged
Phenotype
Prospective Studies

Substances

Blood Glucose
Insulin-Like Growth Factor Binding Protein 2