Cell Biology: Functional Conservation, Structural Divergence, and Surprising Convergence in the MICOS Complex of Trypanosomes

Jeremy G Wideman; Sergio A Muñoz-Gómez

doi:10.1016/j.cub.2018.09.057

Cell Biology: Functional Conservation, Structural Divergence, and Surprising Convergence in the MICOS Complex of Trypanosomes

Curr Biol. 2018 Nov 5;28(21):R1245-R1248. doi: 10.1016/j.cub.2018.09.057.

Authors

Jeremy G Wideman¹, Sergio A Muñoz-Gómez²

Affiliations

¹ Department of Biochemistry and Molecular Biology, Dalhousie University, Halifax, B3H 4R2 Nova Scotia, Canada. Electronic address: [email protected].
² Department of Biochemistry and Molecular Biology, Dalhousie University, Halifax, B3H 4R2 Nova Scotia, Canada. Electronic address: [email protected].

PMID: 30399345
DOI: 10.1016/j.cub.2018.09.057

Abstract

The MICOS complex is conserved across eukaryotes, but little is known about it outside the group that comprises animals and fungi. A new study finds that mitochondria of trypanosomatid parasites bear a divergent MICOS with both ancestral and derived subunits, but with conserved functions in crista development and membrane contact-site formation.

Publication types

Comment

MeSH terms

Animals
Mitochondria
Mitochondrial Membranes
Mitochondrial Proteins*
Trypanosoma*

Substances

Mitochondrial Proteins