Genetic Variations in ABCA7 Can Increase Secreted Levels of Amyloid-β40 and Amyloid-β42 Peptides and ABCA7 Transcription in Cell Culture Models

J Alzheimers Dis. 2018;66(2):853-854. doi: 10.3233/JAD-189009.
No abstract available

MeSH terms

  • ATP-Binding Cassette Transporters / genetics*
  • ATP-Binding Cassette Transporters / metabolism*
  • Amyloid beta-Peptides / metabolism*
  • Cells, Cultured
  • Genetic Variation / genetics*
  • Humans
  • Peptide Fragments / metabolism*

Substances

  • ABCA7 protein, human
  • ATP-Binding Cassette Transporters
  • Amyloid beta-Peptides
  • Peptide Fragments
  • amyloid beta-protein (1-40)
  • amyloid beta-protein (1-42)