[Meta-analysis of voice outcomes after steroid injection on benign vocal fold lesions]

Objective:The aim of this study is to perform a meta-analysis of vocal changes after vocal cord steroid injection (VFSI) in the treatment of benign lesions. Method:Pubmed, Embase, CNKI and Wanfang database were searched using the keywords. A total of 7 articles were characterized based on our keyword search. The chi-square-based I² statistic test was employed to assess the between-study heterogeneity. Additionally, random effects models were used to calculate mean differences with 95% confidence intervals. Result:A total of 344 cases were included in 7 literatures. Meta-analysis demonstrated a significant increase in maximal phonation time(MPT) and decrease Jitter after VFSI.The index and amplitude perturbations were not statistically significant before and after hormone injection. Conclusion:Our results support that VFSI has advantages in terms of voice quality. However, we need more studies with longer follow-up periods to validate our findings.