The Battle between TET Proteins and DNA Methylation for the Right Cell

Trends Cell Biol. 2018 Dec;28(12):973-975. doi: 10.1016/j.tcb.2018.10.002. Epub 2018 Nov 3.

Abstract

DNA methylation is an important epigenetic barrier during somatic cell reprogramming. Yet, how genome-wide methylation is reprogrammed remains largely unknown. Sardina et al. (Cell Stem Cell 2018:https://doi.org/10.1016/j.stem.2018.08.016) address this question by mapping the DNA methylomes of cells undergoing reprogramming and show that TET proteins and transcription factors cooperate to orchestrate demethylation critical to reprogramming.

Keywords: DNA methylation; TET protein; somatic cell reprogramming.

Publication types

  • Comment

MeSH terms

  • Cell Differentiation
  • Cellular Reprogramming*
  • DNA Methylation*
  • Demethylation
  • Transcription Factors

Substances

  • Transcription Factors