Abstract
One of the side-effects of the cytotoxic drug, cisplatin, is its neurotoxicity. In rats this neurotoxicity can be measured as a slowing of the H-reflex-related sensory nerve conduction velocity. Concurrent treatment with Org.2766 (an ACTH4-9 analog) prevents this neurotoxic side effect while leaving the antitumor activity of cisplatin unaffected.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Adrenocorticotropic Hormone / analogs & derivatives*
-
Adrenocorticotropic Hormone / pharmacology
-
Animals
-
Anticonvulsants / pharmacology*
-
Cisplatin / therapeutic use
-
Cisplatin / toxicity*
-
Female
-
H-Reflex / drug effects
-
Muscles / physiology
-
Neoplasms, Experimental / drug therapy
-
Neural Conduction / drug effects
-
Neurons, Afferent / drug effects*
-
Neurons, Afferent / physiology
-
Peptide Fragments / pharmacology*
-
Peripheral Nerves / drug effects*
-
Peripheral Nerves / physiopathology
-
Rats
-
Rats, Inbred Strains
Substances
-
Anticonvulsants
-
Peptide Fragments
-
Org 2766
-
Adrenocorticotropic Hormone
-
Cisplatin