Abstract
Low-density lipoprotein readily undergoes lipid peroxidation that is accompanied by apoprotein fragmentation. Oxidized forms of low-density lipoprotein show altered biological behavior, including changes in receptor recognition and cytotoxicity to cells in culture. In this review, free radical mechanisms and the biological consequences of low-density lipoprotein modification are discussed.
Publication types
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Animals
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Apolipoproteins B / metabolism
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Arteriosclerosis / etiology
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Cell Survival / drug effects
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Free Radicals
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Humans
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Hydrogen Peroxide / metabolism
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Lipid Peroxides / metabolism
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Lipoproteins, LDL / metabolism*
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Lipoproteins, LDL / pharmacology
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Metals / metabolism
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Phospholipases A / metabolism
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Receptors, LDL / drug effects
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Superoxides / metabolism
Substances
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Apolipoproteins B
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Free Radicals
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Lipid Peroxides
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Lipoproteins, LDL
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Metals
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Receptors, LDL
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Superoxides
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Hydrogen Peroxide
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Phospholipases A