Evaluation of 72Se/72As generator and production of 72Se for supplying 72As as a potential PET imaging radionuclide

Appl Radiat Isot. 2019 Jan:143:113-122. doi: 10.1016/j.apradiso.2018.10.026. Epub 2018 Oct 30.

Abstract

Positron-emitting 72As is the PET imaging counterpart for beta-emitting 77As. Its parent, no carrier added (n.c.a.) 72Se, was produced for a 72Se/72As generator by irradiating an enriched 7°Ge metal-graphite target via the 70Ge(α, 2 n)72Se reaction. Target dissolution used a fast, environmentally friendly method with 93% radioactivity recovery. Chromatographic parameters of the 72Se/72As generator were evaluated, the eluted n.c.a. 72As was characterized with a phantom imaging study, and the previously reported trithiol and aryl-dithiol ligand systems were radiolabeled with the separated n.c.a. 72As in high yield.

Keywords: (70)Ge target; (72)As; (72)Se; (72)Se/(72)As generator; Alpha irradiation; Radiolabeling.

Publication types

  • Evaluation Study

MeSH terms

  • Arsenic / isolation & purification*
  • Germanium / chemistry
  • Germanium / isolation & purification
  • Germanium / radiation effects
  • Humans
  • Isotopes / chemistry
  • Isotopes / isolation & purification
  • Isotopes / radiation effects
  • Phantoms, Imaging
  • Positron-Emission Tomography
  • Radioisotopes / isolation & purification*
  • Radioligand Assay
  • Radionuclide Generators*
  • Radiopharmaceuticals / chemical synthesis
  • Radiopharmaceuticals / chemistry
  • Radiopharmaceuticals / isolation & purification*
  • Selenium Radioisotopes / isolation & purification*

Substances

  • Arsenic-72
  • Germanium-70
  • Isotopes
  • Radioisotopes
  • Radiopharmaceuticals
  • Selenium Radioisotopes
  • Selenium-72
  • Selenium-75
  • Germanium
  • Arsenic