Human Leukocyte Antigen Associations in Drug Hypersensitivity Reactions

Clin Lab Med. 2018 Dec;38(4):669-677. doi: 10.1016/j.cll.2018.08.002.

Abstract

Severe adverse drug reactions are a common cause of morbidity and mortality. Some of the most severe reactions are immunologically mediated and have been linked to specific HLA alleles. The mechanisms underlying HLA-associated drug hypersensitivity are complex and not fully understood. Recent findings have provided insight into recognition mechanisms underlying drug-induced immunopathogenesis and criteria for increasing positive prediction of hypersensitivity. Refining pharmocogenetic testing strategies to better identify at-risk individuals can improve hypersensitivity prevention and mechanism characterization.

Keywords: ADRs; Abacavir; Adverse drug reactions; Dapsone; HLA; HLA associated; Hypersensitivity; Prediction.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Drug Hypersensitivity* / genetics
  • Drug Hypersensitivity* / immunology
  • Genetic Predisposition to Disease / genetics*
  • HLA Antigens* / genetics
  • HLA Antigens* / immunology
  • Humans

Substances

  • HLA Antigens