High-Dosage Cefazolin Achieves Sufficient Cerebrospinal Diffusion To Treat an External Ventricular Drainage-Related Staphylococcus aureus Ventriculitis

Antimicrob Agents Chemother. 2019 Jan 29;63(2):e01844-18. doi: 10.1128/AAC.01844-18. Print 2019 Feb.

Abstract

A patient received continuous infusion of cefazolin 10 g then 8 g daily for an external ventricular drainage-related methicillin-susceptible Staphylococcus aureus (MSSA) ventriculitis. Median free concentrations in the cerebrospinal fluid were 11.9 and 6.1 mg/liter after 10- and 8-g doses, respectively. Free concentrations in the cerebrospinal fluid were always above the MIC usually displayed by methicillin-susceptible Staphylococcus aureus (MSSA) isolates. These results support the use of high-dose cefazolin to achieve sufficient meningeal concentrations.

Keywords: cefazolin; cerebrospinal fluid; healthcare-associated infection; meningitis; pharmacokinetics.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Anti-Bacterial Agents / administration & dosage
  • Anti-Bacterial Agents / therapeutic use
  • Cefazolin / administration & dosage
  • Cefazolin / therapeutic use*
  • Cerebral Ventriculitis / drug therapy*
  • Cerebral Ventriculitis / microbiology
  • Humans
  • Meningitis / drug therapy
  • Meningitis / microbiology
  • Microbial Sensitivity Tests
  • Staphylococcal Infections / drug therapy
  • Staphylococcal Infections / microbiology
  • Staphylococcus aureus / drug effects
  • Staphylococcus aureus / pathogenicity*

Substances

  • Anti-Bacterial Agents
  • Cefazolin