CHAF1B Overexpression: A Brake for the Differentiation of Leukemia Cells

Qing Li; Xu Zhang; Zhiguo Zhang

doi:10.1016/j.ccell.2018.10.011

CHAF1B Overexpression: A Brake for the Differentiation of Leukemia Cells

Cancer Cell. 2018 Nov 12;34(5):693-694. doi: 10.1016/j.ccell.2018.10.011.

Authors

Qing Li¹, Xu Zhang², Zhiguo Zhang³

Affiliations

¹ State Key Laboratory of Protein and Plant Gene Research, School of Life Sciences and Peking-Tsinghua Center for Life Sciences, Peking University, Beijing 100871, China. Electronic address: [email protected].
² Institute for Cancer Genetics and Department of Pediatrics and Genetics and Development, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.
³ Institute for Cancer Genetics and Department of Pediatrics and Genetics and Development, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA. Electronic address: [email protected].

Abstract

In this issue of Cancer Cell, Volk et al. report that overexpression of CHAF1B displaces myeloid transcription factors from chromatin, and deletion of CHAF1B promotes differentiation of leukemia cells and suppresses leukemogenesis in a murine model, revealing a causal role of and an unexpected mechanism for CHAF1B overexpression in tumorigenesis.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Comment

MeSH terms

Animals
Carcinogenesis
Cell Differentiation
Hematopoiesis
Leukemia, Myeloid, Acute*
Mice
Transcription Factors

Substances

Transcription Factors

Abstract

Publication types

MeSH terms

Substances

Grants and funding