More Is More: Semiannual Breast MRI Screening in BRCA1 Mutation Carriers

Clin Cancer Res. 2019 Mar 15;25(6):1693-1695. doi: 10.1158/1078-0432.CCR-18-3145. Epub 2018 Nov 14.

Abstract

Although annual MRI screening has improved early diagnosis of hereditary breast cancer, fast growth rates of BRCA1-associated cancers can still lead to interval cancers and/or node-positive disease. Using MRI with shorter screening intervals helps to effectively avoid both interval cancers and node-positive stages, whereas there is no role for mammography in these women.See related article by Guindalini et al., p. 1786.

Publication types

  • Comment

MeSH terms

  • BRCA1 Protein
  • Breast Neoplasms / genetics*
  • Early Detection of Cancer
  • Female
  • Genes, BRCA1
  • Humans
  • Magnetic Resonance Imaging
  • Mammography
  • Mutation

Substances

  • BRCA1 Protein
  • BRCA1 protein, human