Sex Bias in Sepsis

Cell Host Microbe. 2018 Nov 14;24(5):613-615. doi: 10.1016/j.chom.2018.10.014.

Abstract

Though critical for preventing fatal sepsis, the mechanisms mediating the capture of bloodstream bacteria are incompletely understood. New work by Zeng et al. (2018) demonstrates that estrogen-regulated innate antibodies protect females and newborns from death following bloodstream infection with enteropathogenic Eschericia coli.

MeSH terms

  • Animals
  • Antibodies, Bacterial / immunology
  • Complement C3 / immunology
  • Enteropathogenic Escherichia coli
  • Escherichia coli / immunology
  • Escherichia coli Infections / immunology
  • Estrogens / immunology
  • Female
  • Gastrointestinal Microbiome / immunology
  • Humans
  • Immunity, Innate / immunology*
  • Immunoglobulin G / immunology
  • Immunoglobulin M / immunology
  • Liver / immunology
  • Liver / metabolism
  • Male
  • Maternal-Fetal Exchange / immunology
  • Mice
  • Mice, Knockout
  • Pregnancy
  • Sepsis / immunology
  • Sepsis / microbiology
  • Sepsis / prevention & control*
  • Serum / immunology
  • Sex Factors*

Substances

  • Antibodies, Bacterial
  • C3 protein, mouse
  • Complement C3
  • Estrogens
  • Immunoglobulin G
  • Immunoglobulin M