Update on Pathogenesis of Opisthorchiasis and Cholangiocarcinoma

Banchob Sripa; Sirikachorn Tangkawattana; Paul J Brindley

doi:10.1016/bs.apar.2018.10.001

Update on Pathogenesis of Opisthorchiasis and Cholangiocarcinoma

Adv Parasitol. 2018:102:97-113. doi: 10.1016/bs.apar.2018.10.001. Epub 2018 Oct 22.

Authors

Banchob Sripa¹, Sirikachorn Tangkawattana², Paul J Brindley³

Affiliations

¹ Department of Pathology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand; WHO Collaborating Centre for Research and Control of Opisthorchiasis (Southeast Asian Liver Fluke Disease); Tropical Disease Research Center, Khon Kaen University, Khon Kaen, Thailand.
² Faculty of Veterinary Medicine, Khon Kaen University, Khon Kaen, Thailand; WHO Collaborating Centre for Research and Control of Opisthorchiasis (Southeast Asian Liver Fluke Disease); Tropical Disease Research Center, Khon Kaen University, Khon Kaen, Thailand.
³ Department of Microbiology, Immunology and Tropical Medicine, Research Center for Neglected Diseases of Poverty, School of Medicine and Health Sciences, George Washington University, Washington DC, United States.

PMID: 30442312
DOI: 10.1016/bs.apar.2018.10.001

Abstract

Infection with the food-borne liver fluke Opisthorchis viverrini causes cholangiocarcinoma (CCA). Whereas the cause of CCA in the West remains obscure, the principal risk factor in Thailand is opisthorchiasis. Here, we review recent findings on the pathogenesis of opisthorchiasis and CCA focusing on helminth molecules/toxic metabolites, host-parasite interaction, endocytosis, immunopathology/inflammatory responses, free radical production, molecular genetic alterations, and multifactorial including coinfections driving to CCA development.

Keywords: Bile duct; Cholangiocarcinoma; Helicobacter; Immunopathology; Inflammation; Opisthorchiasis; Opisthorchis viverrini; Pathogenesis.

Publication types

Review

MeSH terms

Animals
Bile Duct Neoplasms / etiology*
Cholangiocarcinoma / etiology*
Host-Parasite Interactions*
Humans
Opisthorchiasis / complications*
Opisthorchiasis / immunology
Opisthorchiasis / pathology
Opisthorchis

Grants and funding

P50 AI098639/AI/NIAID NIH HHS/United States