The interdependence of gene-regulatory elements and the 3D genome

J Cell Biol. 2019 Jan 7;218(1):12-26. doi: 10.1083/jcb.201809040. Epub 2018 Nov 15.

Abstract

Imaging studies, high-resolution chromatin conformation maps, and genome-wide occupancy data of architectural proteins have revealed that genome topology is tightly intertwined with gene expression. Cross-talk between gene-regulatory elements is often organized within insulated neighborhoods, and regulatory cues that induce transcriptional changes can reshape chromatin folding patterns and gene positioning within the nucleus. The cause-consequence relationship of genome architecture and gene expression is intricate, and its molecular mechanisms are under intense investigation. Here, we review the interdependency of transcription and genome organization with emphasis on enhancer-promoter contacts in gene regulation.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Cycle / genetics
  • Cell Nucleus / genetics
  • Cell Nucleus / metabolism
  • Cell Nucleus / ultrastructure
  • Chromatin / metabolism
  • Chromatin / ultrastructure
  • Enhancer Elements, Genetic*
  • Gene Expression Regulation
  • Gene Regulatory Networks
  • Genome*
  • Humans
  • Promoter Regions, Genetic*

Substances

  • Chromatin