JAK 1/2 Blockade in MDA5 Gain-of-Function

J Clin Immunol. 2018 Nov;38(8):844-846. doi: 10.1007/s10875-018-0563-2. Epub 2018 Nov 15.
No abstract available

Publication types

  • Case Reports
  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alopecia
  • Antibodies, Antinuclear / blood
  • Child
  • Child, Preschool
  • Female
  • Humans
  • Immunosuppressive Agents / therapeutic use*
  • Infant
  • Infant, Newborn
  • Interferon Type I / genetics
  • Interferon-Induced Helicase, IFIH1 / genetics*
  • Janus Kinase 1 / antagonists & inhibitors
  • Janus Kinase 2 / antagonists & inhibitors
  • Lupus Erythematosus, Systemic / diagnosis
  • Lupus Erythematosus, Systemic / drug therapy*
  • Lupus Erythematosus, Systemic / genetics
  • Motor Disorders
  • Mutation / genetics*
  • Neopterin / cerebrospinal fluid
  • Nervous System Diseases / diagnosis
  • Nervous System Diseases / drug therapy*
  • Nervous System Diseases / genetics
  • Nitriles
  • Pyrazoles / pharmacology
  • Pyrazoles / therapeutic use*
  • Pyrimidines
  • Up-Regulation

Substances

  • Antibodies, Antinuclear
  • Immunosuppressive Agents
  • Interferon Type I
  • Nitriles
  • Pyrazoles
  • Pyrimidines
  • Neopterin
  • ruxolitinib
  • Janus Kinase 1
  • Janus Kinase 2
  • IFIH1 protein, human
  • Interferon-Induced Helicase, IFIH1