Macrophage functions in wound healing

Malgorzata Kloc; Rafik M Ghobrial; Jarek Wosik; Aneta Lewicka; Sławomir Lewicki; Jacek Z Kubiak

doi:10.1002/term.2772

Macrophage functions in wound healing

J Tissue Eng Regen Med. 2019 Jan;13(1):99-109. doi: 10.1002/term.2772. Epub 2018 Dec 13.

Authors

Malgorzata Kloc^{1

2

3}, Rafik M Ghobrial^{1

2}, Jarek Wosik^{4

5}, Aneta Lewicka⁶, Sławomir Lewicki⁷, Jacek Z Kubiak^{7

8}

Affiliations

¹ Immunobiology, The Houston Methodist Research Institute, Houston, Texas, USA.
² Department of Surgery, The Houston Methodist Hospital, Houston, Texas, USA.
³ MD Anderson Cancer Center, University of Texas, Houston, Texas, USA.
⁴ Electrical and Computer Engineering Department, University of Houston, Houston, Texas, USA.
⁵ Texas Center for Superconductivity, University of Houston, Houston, Texas, USA.
⁶ Laboratory of Epidemiology, Military Institute of Hygiene and Epidemiology (WIHE), Warsaw, Poland.
⁷ Department of Regenerative Medicine and Cell Biology, Military Institute of Hygiene and Epidemiology (WIHE), Warsaw, Poland.
⁸ Cell Cycle Group, Faculty of Medicine, Univ Rennes, UMR 6290, CNRS, Institute of Genetics and Development of Rennes, Rennes, France.

PMID: 30445662
DOI: 10.1002/term.2772

Abstract

Macrophages play a crucial role in regeneration and consecutive phases of wound healing. In this review, we summarise current knowledge on the ontogeny, origin, phenotypical heterogeneity, and functional exchangeability of macrophages participating in these processes. We also describe the genetic, pharmacologic, and bioengineering methods for manipulation of macrophage phenotype and functions and their potential for development of the novel, clinically applicable therapies.

Keywords: CX3CR1; ROCK kinase; RhoAactin; macrophages; wound healing.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Humans
Macrophages / metabolism*
Macrophages / pathology
Wound Healing*