Sporadic pancreatic neuroendocrine tumor: Surgery of the primary tumor

J Visc Surg. 2018 Dec;155(6):483-492. doi: 10.1016/j.jviscsurg.2018.08.010. Epub 2018 Nov 15.

Abstract

The management of patients with sporadic pancreatic neuroendocrine tumors (PNET) is multi-disciplinary and often, multimodal. Surgery has a large part in treatment because it is the only potentially curative therapeutic modality if resection can be complete. The update reviews the operative indications and the different surgical techniques available (including parenchymal-sparing surgery) to treat the primary lesion according to patient status, preoperative work-up and whether the tumor is functioning or not. The place of observation for "small" non-functional sporadic PNET is also discussed.

Keywords: Pancreatic surgery; Post-operative morbi-mortality; Sporadic neuroendocrine tumors.

Publication types

  • Review

MeSH terms

  • Gastrinoma / surgery
  • Humans
  • Incidental Findings
  • Insulinoma / surgery
  • Liver Neoplasms / secondary
  • Liver Neoplasms / surgery
  • Neoadjuvant Therapy
  • Neuroendocrine Tumors / diagnostic imaging
  • Neuroendocrine Tumors / surgery*
  • Organ Sparing Treatments
  • Pancreatic Neoplasms / diagnostic imaging
  • Pancreatic Neoplasms / surgery*
  • Pancreaticoduodenectomy / methods
  • Tomography, X-Ray Computed

Supplementary concepts

  • Non functioning pancreatic endocrine tumor