Catalytic C1 Alkylation with Methanol and Isotope-Labeled Methanol

Jan Sklyaruk; Jannik C Borghs; Osama El-Sepelgy; Magnus Rueping

doi:10.1002/anie.201810885

Catalytic C₁ Alkylation with Methanol and Isotope-Labeled Methanol

Angew Chem Int Ed Engl. 2019 Jan 14;58(3):775-779. doi: 10.1002/anie.201810885. Epub 2018 Dec 17.

Authors

Jan Sklyaruk¹, Jannik C Borghs¹, Osama El-Sepelgy¹, Magnus Rueping^{1

2}

Affiliations

¹ Institute of Organic Chemistry, RWTH Aachen University, Landoltweg 1, 52074, Aachen, Germany.
² KAUST Catalysis Center (KCC), King Abdullah University of Science and Technology (KAUST), Thuwal, 23955-6900, Saudi Arabia.

PMID: 30457690
DOI: 10.1002/anie.201810885

Abstract

A metal-catalyzed methylation process has been developed. By employing an air- and moisture-stable manganese catalyst together with isotopically labeled methanol, a series of D-, CD₃ -, and ¹³ C-labeled products were obtained in good yields under mild reaction conditions with water as the only byproduct.

Keywords: alkylation; manganese; methylation; transition-metal catalysis; trideuteromethylation.

Publication types

Research Support, Non-U.S. Gov't