Pediatric lupus nephritis

J Bras Nefrol. 2019 Apr-Jun;41(2):252-265. doi: 10.1590/2175-8239-JBN-2018-0097. Epub 2018 Nov 14.
[Article in English, Portuguese]

Abstract

Involvement of the kidneys by lupus nephritis (LN) is one of the most severe clinical manifestations seen in individuals with systemic lupus erythematosus (SLE). LN is more frequent and severe in pediatric patients and has been associated with higher morbidity and mortality rates. This narrative review aimed to describe the general aspects of LN and its particularities when affecting children and adolescents, while focusing on the disease's etiopathogenesis, clinical manifestations, renal tissue alterations, and treatment options.

Publication types

  • Review

MeSH terms

  • Adolescent
  • Biomarkers / blood
  • Biomarkers / urine
  • Child
  • Child, Preschool
  • Early Diagnosis
  • Female
  • Humans
  • Infant
  • Infant, Newborn
  • Lupus Nephritis / diagnosis
  • Lupus Nephritis / drug therapy
  • Lupus Nephritis / epidemiology*
  • Lupus Nephritis / pathology*
  • Male
  • Prevalence
  • Rare Diseases / diagnosis
  • Rare Diseases / drug therapy
  • Rare Diseases / epidemiology*
  • Rare Diseases / pathology*

Substances

  • Biomarkers