Potential roles of IL-1 subfamily members in glycolysis in disease

Qi Tan; Qi Huang; Yan Ling Ma; KaiMin Mao; GuangHai Yang; Ping Luo; GuanZhou Ma; PeiYuan Mei; Yang Jin

doi:10.1016/j.cytogfr.2018.11.001

Potential roles of IL-1 subfamily members in glycolysis in disease

Cytokine Growth Factor Rev. 2018 Dec:44:18-27. doi: 10.1016/j.cytogfr.2018.11.001. Epub 2018 Nov 16.

Authors

Qi Tan¹, Qi Huang², Yan Ling Ma³, KaiMin Mao⁴, GuangHai Yang⁵, Ping Luo⁶, GuanZhou Ma⁷, PeiYuan Mei⁸, Yang Jin⁹

Affiliations

¹ Department of Respiratory and Critical Care Medicine, NHC Key Laboratory of Pulmonary Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China. Electronic address: [email protected].
² Department of Respiratory and Critical Care Medicine, NHC Key Laboratory of Pulmonary Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China. Electronic address: [email protected].
³ Department of Respiratory and Critical Care Medicine, NHC Key Laboratory of Pulmonary Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China. Electronic address: [email protected].
⁴ Department of Respiratory and Critical Care Medicine, NHC Key Laboratory of Pulmonary Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China. Electronic address: [email protected].
⁵ Department of Thoracic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China. Electronic address: [email protected].
⁶ Center for Translational Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China. Electronic address: [email protected].
⁷ Department of Respiratory and Critical Care Medicine, NHC Key Laboratory of Pulmonary Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China. Electronic address: [email protected].
⁸ Department of Thoracic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China. Electronic address: [email protected].
⁹ Department of Respiratory and Critical Care Medicine, NHC Key Laboratory of Pulmonary Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China. Electronic address: [email protected].

PMID: 30470512
DOI: 10.1016/j.cytogfr.2018.11.001

Abstract

The interleukin-(IL)-1 subfamily consists of IL-1α, IL-1β, IL-1 receptor antagonist IL-1Ra and IL-33. These cytokines are the main members of the IL-1 family and have been widely recognized as having significant roles in pro-inflammatory and immunomodulatory actions. Mounting evidence has revealed that these cytokines also play key roles in the regulation of glycolysis, which is an important metabolic pathway in most organisms that provides energy. Dysregulation of glycolysis is associated with various diseases, including type 2 diabetes, rheumatoid arthritis (RA) and cancer. We reviewed studies addressing the important roles of IL-1 subfamily cytokines, with particular focus on their ability to regulate glycolysis in disease states. In this review, we summarize the potential roles of IL-1 subfamily members in glycolysis in disease states and address the underlying mechanisms. Furthermore, we discuss the potential of these cytokines as therapeutic targets in clinical applications to provide insight into possible therapeutic strategies for treatment, especially for cancers.

Keywords: Glycolysis; IL-1Ra; IL-1α; IL-1β; IL-33; Metabolism.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Arthritis, Rheumatoid / metabolism
Diabetes Mellitus, Type 2 / metabolism
Glycolysis*
Humans
Interleukin-1 / metabolism*
Neoplasms / metabolism
Protein Subunits / metabolism*

Substances

Interleukin-1
Protein Subunits