Repeatability of Regional Lung Ventilation Quantification Using Fluorinated (19F) Gas Magnetic Resonance Imaging

Marcel Gutberlet; Till F Kaireit; Andreas Voskrebenzev; Agilo L Kern; Arnd Obert; Frank Wacker; Jens M Hohlfeld; Jens Vogel-Claussen

doi:10.1016/j.acra.2018.10.021

Repeatability of Regional Lung Ventilation Quantification Using Fluorinated (¹⁹F) Gas Magnetic Resonance Imaging

Acad Radiol. 2019 Mar;26(3):395-403. doi: 10.1016/j.acra.2018.10.021. Epub 2018 Nov 22.

Authors

Marcel Gutberlet¹, Till F Kaireit¹, Andreas Voskrebenzev¹, Agilo L Kern¹, Arnd Obert¹, Frank Wacker¹, Jens M Hohlfeld², Jens Vogel-Claussen³

Affiliations

¹ Institute for Diagnostic and Interventional Radiology, Hannover Medical School, Carl-Neuberg-Str. 1, Hannover 30625, Germany; Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Member of the German Center for Lung Research, Hannover, Germany.
² Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Member of the German Center for Lung Research, Hannover, Germany; Clinic of Pneumology, Hannover Medical School, Hannover, Germany; Fraunhofer Institute for Toxicology and Experimental Medicine, Clinical Airway Research, Hannover, Germany.
³ Institute for Diagnostic and Interventional Radiology, Hannover Medical School, Carl-Neuberg-Str. 1, Hannover 30625, Germany; Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Member of the German Center for Lung Research, Hannover, Germany. Electronic address: [email protected].

PMID: 30472224
DOI: 10.1016/j.acra.2018.10.021

Abstract

Rationale and objectives: To assess the repeatability of global and regional lung ventilation quantification in both healthy subjects and patients with chronic obstructive pulmonary disease (COPD) using fluorinated (¹⁹F) gas washout magnetic resonance (MR) imaging in free breathing.

Material and methods: In this prospective institutional review board-approved study, 12 healthy nonsmokers and eight COPD patients were examined with ¹⁹F dynamic gas washout MR imaging in free breathing and with lung function testing. Measurements were repeated within 2 weeks. Lung ventilation was quantified using ¹⁹F gas washout time. Repeatability was analyzed for the total lung and on a regional basis using the coefficient of variation (COV) and Bland-Altman plots.

Results: In healthy subjects and COPD patients, a good repeatability was found for lung ventilation quantification using dynamic ¹⁹F gas washout MR imaging on a global (COV < 8%) and regional (COV < 15%) level. Gas washout time was significantly increased in the COPD group compared to the healthy subjects.

Conclusion: ¹⁹F gas washout MR imaging provides a good repeatability of lung ventilation quantification and appears to be sensitive to early changes of regional lung function alterations such as normal aging.

Keywords: (19)F; COPD; Fluorine; Gas washout; Lung; Magnetic resonance; Pulmonary.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Aged
Case-Control Studies
Female
Fluorine-19 Magnetic Resonance Imaging / methods*
Humans
Lung / diagnostic imaging
Lung / physiology*
Male
Middle Aged
Prospective Studies
Pulmonary Disease, Chronic Obstructive / diagnostic imaging*
Pulmonary Disease, Chronic Obstructive / physiopathology*
Pulmonary Ventilation*
Reproducibility of Results
Respiration
Young Adult