Telomere Length in Workers Was Effected by Omethoate Exposure, GSTM1 Deletion, Interaction Between Smoking and GSTP1 Polymorphisms

Wei Wang; Hui Zhang; Xiaoran Duan; Xiaolei Feng; Tuanwei Wang; Pengpeng Wang; Mingcui Ding; Suxiang Liu; Lei Li; Junling Liu; Lixia Tang; Xinhua Niu; Yuhong Zhang; Guoyu Li; Wu Yao; Yongli Yang

doi:10.1097/JOM.0000000000001503

Telomere Length in Workers Was Effected by Omethoate Exposure, GSTM1 Deletion, Interaction Between Smoking and GSTP1 Polymorphisms

J Occup Environ Med. 2019 Jan;61(1):e19-e23. doi: 10.1097/JOM.0000000000001503.

Authors

Wei Wang¹, Hui Zhang, Xiaoran Duan, Xiaolei Feng, Tuanwei Wang, Pengpeng Wang, Mingcui Ding, Suxiang Liu, Lei Li, Junling Liu, Lixia Tang, Xinhua Niu, Yuhong Zhang, Guoyu Li, Wu Yao, Yongli Yang

Affiliation

¹ Department of Occupational Health and Occupational Diseases (Drs W. Wang, H. Zhang, Duan, Feng, T. Wang, P. Wang, Ding, Yao); Clinical Department, Zhengzhou Institute of Occupational Health (Drs S. Liu, Li, J. Liu, Tang, Niu, Y. Zhang, Li); Department of Epidemiology and Biostatistics (Dr Yang), College of Public Health, Zhengzhou University, Zhengzhou, China.

PMID: 30475314
DOI: 10.1097/JOM.0000000000001503

Abstract

Objective: The aim of this study was to explore the association between telomere length and metabolizing enzyme gene polymorphisms and environmental factors in omethoate-exposed workers.

Methods: The gene-environment interactions were analyzed with generalized linear model method.

Results: The relative telomere lengths in the individuals with GSTM1-deletion were longer than that in non-deletion genotype in the control group (P = 0.011); the relative telomere lengths with GG+AG genotypes in GSTP1 rs1695 were longer than that of AA genotype in the exposure group (P = 0.039). The interaction between the GG+AG genotypes in GSTP1 rs1695 and smoking exposure had significant effect on telomere length (P < 0.05).

Conclusions: The prolongation of relative telomere length in omethoate-exposed workers was associated with GSTM1-deletion, GG+AG genotypes, and interactions of GG+AG genotypes and smoking factor.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Case-Control Studies
Dimethoate / adverse effects
Dimethoate / analogs & derivatives*
Female
Gene Deletion
Gene-Environment Interaction
Glutathione S-Transferase pi / genetics*
Glutathione Transferase / genetics*
Humans
Male
Occupational Exposure / adverse effects*
Occupational Exposure / statistics & numerical data
Polymorphism, Single Nucleotide / genetics
Smoking / adverse effects*
Telomere / drug effects*
Telomere / genetics

Substances

dimethoxon
GSTP1 protein, human
Glutathione S-Transferase pi
Glutathione Transferase
glutathione S-transferase M1
Dimethoate