Reply to 'Selective effects of heterozygous protein-truncating variants'
Nat Genet
.
2019 Jan;51(1):3-4.
doi: 10.1038/s41588-018-0301-y.
Authors
Christopher A Cassa
#
1
2
3
,
Donate Weghorn
#
1
2
4
,
Daniel J Balick
#
1
2
,
Daniel M Jordan
#
5
,
David Nusinow
1
,
Kaitlin E Samocha
6
7
,
Anne O'Donnell-Luria
6
8
,
Daniel G MacArthur
3
6
,
Mark J Daly
3
6
,
David R Beier
9
10
,
Shamil R Sunyaev
11
12
13
Affiliations
1
Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
2
Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.
3
Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA.
4
Centre for Genomic Regulation, Barcelona, Spain.
5
Department of Genetic and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
6
Analytic and Translational Genetics Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
7
Program in Biological and Biomedical Sciences, Harvard Medical School, Boston, MA, USA.
8
Division of Genetics and Genomics, Boston Children's Hospital, Boston, MA, USA.
9
Center for Developmental Biology and Regenerative Medicine, Seattle Children's Research Institute, Seattle, WA, USA.
[email protected]
.
10
Department of Pediatrics, University of Washington School of Medicine, Seattle, WA, USA.
[email protected]
.
11
Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
[email protected]
.
12
Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.
[email protected]
.
13
Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA.
[email protected]
.
#
Contributed equally.
PMID:
30478437
PMCID:
PMC9196138
DOI:
10.1038/s41588-018-0301-y
No abstract available
Publication types
Letter
Comment
MeSH terms
Exome*
Heterozygote
Grants and funding
R01 HG010372/HG/NHGRI NIH HHS/United States