Synthesis of Cyclopenta[ b]piperazinones via an Azaoxyallyl Cation

Org Lett. 2018 Dec 7;20(23):7405-7409. doi: 10.1021/acs.orglett.8b03103. Epub 2018 Nov 27.

Abstract

A new and efficient reaction sequence between 2-furylcarbinols, anilines, and α-haloamides has been developed to afford highly functionalized cyclopenta[ b]piperazinones. This transformation was accomplished through an aza-Piancatelli cyclization/azaoxyallyl cation trapping with a complete control of the diastereoselectivity.

Publication types

  • Research Support, Non-U.S. Gov't