Hydrogen sulfide alleviates oxidative damage under excess nitrate stress through MAPK/NO signaling in cucumber

Plant Physiol Biochem. 2019 Feb:135:1-8. doi: 10.1016/j.plaphy.2018.11.017. Epub 2018 Nov 15.

Abstract

Hydrogen sulfide (H2S) is emerging as a potential messenger molecule involved in modulation of physiological processes in plants. Mitogen-activated protein kinase (MAPK) and nitric oxide (NO) are essential for abiotic stress signaling. This work investigated the effects of H2S and the crosstalk between H2S, MAPK and NO in cucumber roots under nitrate stress. The inhibitory effect of 140 mM nitrate on the growth of shoot and root was substantially alleviated by treatment with H2S donor sodium hydrosulfide (NaHS), especially 100 μM NaHS. Treatment with 100 μM NaHS reduced malondialdehyde (MDA) and H2O2 contents, ROS accumulation and increased the activities of superoxide dismutase (SOD), catalase (CAT), peroxidase (POD) and ascorbate peroxidase (APX). CsNMAPK transcript level was up-regulated by NaHS treatment, while significantly decreased by propargylglycine (PAG, specific inhibitor of H2S biosynthesis) and hypotaurine (HT, H2S scavenger) in cucumber roots under nitrate stress. NO accumulation was increased by NaHS treatment under nitrate stress, but reduced by HT, PAG and PD98059, indicating that NO might function downstream of MAPK and H2S. MAPK inhibitor PD98059 and NO scavenger (cPTIO) reversed the alleviating effect of H2S by increasing MDA and H2O2 contents, and decreasing antioxidant enzyme activities of SOD, CAT, POD, APX, and the endogenous H2S contents and LCD activities under nitrate stress. In conclusion, H2S played a protective role in cucumber seedlings under nitrate stress and MAPK/NO signaling were involved in the process by regulating antioxidant enzyme activities.

Keywords: Cucumber; Hydrogen sulfide; MAPK; Nitrate stress; Nitric oxide.

MeSH terms

  • Ascorbate Peroxidases / metabolism
  • Catalase / metabolism
  • Cucumis sativus / drug effects*
  • Cucumis sativus / metabolism
  • Cucumis sativus / physiology
  • Hydrogen Peroxide / metabolism
  • Hydrogen Sulfide / pharmacology*
  • MAP Kinase Signaling System / drug effects*
  • Malondialdehyde / metabolism
  • Nitrates / pharmacology*
  • Nitric Oxide / metabolism*
  • Oxidative Stress / drug effects*
  • Peroxidase / metabolism
  • Reactive Oxygen Species / metabolism
  • Real-Time Polymerase Chain Reaction
  • Signal Transduction / drug effects*
  • Superoxide Dismutase / metabolism

Substances

  • Nitrates
  • Reactive Oxygen Species
  • Nitric Oxide
  • Malondialdehyde
  • Hydrogen Peroxide
  • Ascorbate Peroxidases
  • Catalase
  • Peroxidase
  • Superoxide Dismutase
  • Hydrogen Sulfide