The lung and gut microbiome: what has to be taken into consideration for cystic fibrosis?

Geneviève Héry-Arnaud; Sébastien Boutin; Leah Cuthbertson; Stuart J Elborn; Michael M Tunney

doi:10.1016/j.jcf.2018.11.003

The lung and gut microbiome: what has to be taken into consideration for cystic fibrosis?

J Cyst Fibros. 2019 Jan;18(1):13-21. doi: 10.1016/j.jcf.2018.11.003. Epub 2018 Nov 25.

Authors

Geneviève Héry-Arnaud¹, Sébastien Boutin², Leah Cuthbertson³, Stuart J Elborn⁴, Michael M Tunney⁵

Affiliations

¹ Univ Brest, Inserm, EFS, UMR 1078, GGB, F-29200 Brest, France; Unité de Bactériologie, Pôle de Biologie-Pathologie, Hôpital La Cavale Blanche, CHRU de Brest, Brest, France. Electronic address: [email protected].
² Department of Infectious Diseases, Medical Microbiology and Hygiene, Heidelberg University Hospital, Heidelberg, Germany; Translational Lung Research Center Heidelberg (TLRC), German Center for Lung Research (DZL), Heidelberg, Germany.
³ National Heart and Lung Institute, Imperial College, London, UK.
⁴ National Heart and Lung Institute, Imperial College, London, UK; Halo Research Group, Centre for Experimental Medicine, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, UK.
⁵ Halo Research Group, School of Pharmacy, Queen's University Belfast, Belfast, UK.

PMID: 30487080
DOI: 10.1016/j.jcf.2018.11.003

Abstract

The 15th European Cystic Fibrosis Society (ECFS) Basic Science pre-conference Symposium focused on the topic of the microbiome, asking the question "The lung and gut microbiome: what has to be considered for cystic fibrosis (CF)?" This review gives an overview of the main points raised during the symposium, which dealt with the technical considerations, pathophysiology and clinical implications of the microbiome in CF.

Keywords: Cystic Fibrosis; Dysbiosis; Gut; Lung; Microbiome.

Publication types

Review

MeSH terms

Cystic Fibrosis / microbiology*
Gastrointestinal Microbiome / physiology
Humans
Intestines / microbiology*
Lung / microbiology*
Microbiota / physiology*