Periodontal Tissue Regeneration Using Brain-Derived Neurotrophic Factor Delivered by Collagen Sponge

Tissue Eng Part A. 2019 Aug;25(15-16):1072-1083. doi: 10.1089/ten.TEA.2018.0209. Epub 2019 Jan 30.

Abstract

The various roles played by brain-derived neurotrophic factor (BDNF) in a multitude of tissues and at different scenarios have rendered BDNF a favorable candidate for improving tissue regeneration. Although the tested formulations of BDNF quantitatively regenerate tissue to a level similar to control groups, it resulted in significantly more instances of full regeneration.

Keywords: BDNF; brain-derived neurotrophic factor; collagen sponge; emdogain; periodontal regeneration.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Bone Regeneration / drug effects
  • Brain-Derived Neurotrophic Factor / pharmacology*
  • Collagen / pharmacology*
  • Dental Cementum / drug effects
  • Dental Cementum / physiology
  • Dogs
  • Epithelium / drug effects
  • Female
  • Imaging, Three-Dimensional
  • Periodontium / diagnostic imaging
  • Periodontium / drug effects
  • Periodontium / physiology*
  • Regeneration / physiology*
  • X-Ray Microtomography

Substances

  • Brain-Derived Neurotrophic Factor
  • Collagen