The Isoform Selective Roles of PI3Ks in Dendritic Cell Biology and Function

Front Immunol. 2018 Nov 15:9:2574. doi: 10.3389/fimmu.2018.02574. eCollection 2018.

Abstract

Phosphoinositide-3 kinases (PI3Ks) generate 3-phosphorylated phosphoinositide lipids that are implicated in many biological processes in homeostatic states and pathologies such as cancer, inflammation and autoimmunity. Eight isoforms of PI3K exist in mammals and among them the class I PI3K, p110γ, and PI3Kδ, and class III Vps34 being the most expressed and well characterized in immune cells. Following engagement of pathogen recognition receptors (PRRs), PI3Ks coordinate vital cellular processes of signaling and vesicular trafficking in innate phagocytes such as macrophages and professional antigen presenting dendritic cells (DCs). Although previous studies demonstrated the involvement of PI3K isoforms in innate and adaptive immune cell types, the role of PI3Ks with respect to DC biology has been enigmatic. Thus, this review, based on studies involving PI3K isoforms, highlight how the different PI3Ks isoforms could regulate DC functions such as antigen processing and presentation including PRR responses.

Keywords: PI3K; antigen presentation; dendritic cell; phospholipids; toll like receptors.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adaptive Immunity
  • Animals
  • Antigen Presentation
  • Autoimmune Diseases / metabolism*
  • Dendritic Cells / immunology*
  • Humans
  • Immunity, Innate
  • Inflammation / metabolism*
  • Neoplasms / metabolism*
  • Phosphatidylinositol 3-Kinases / metabolism*
  • Protein Isoforms / metabolism*
  • Receptors, Pattern Recognition / metabolism
  • Signal Transduction

Substances

  • Protein Isoforms
  • Receptors, Pattern Recognition
  • Phosphatidylinositol 3-Kinases