Facile synthesis of unnatural β-germyl-α-amino amides via Pd(ii)-catalyzed primary and secondary C(sp3)-H bond germylation

Chem Commun (Camb). 2018 Dec 13;54(100):14136-14139. doi: 10.1039/c8cc08098d.

Abstract

Pd(ii)-Catalyzed direct C(sp3)-H germylation of α-AA derivatives with the assistance of a bidentate auxiliary for the efficient synthesis of β-germyl-α-amino amides is reported. This protocol features good generality for primary and secondary C-H bonds of aliphatic amides. Mechanistic studies show that a crucial five-membered palladacycle intermediate may play a key role in this process.