Contemporary medicinal-chemistry strategies for the discovery of selective butyrylcholinesterase inhibitors

Lanlan Jing; Gaochan Wu; Dongwei Kang; Zhongxia Zhou; Yuning Song; Xinyong Liu; Peng Zhan

doi:10.1016/j.drudis.2018.11.012

Contemporary medicinal-chemistry strategies for the discovery of selective butyrylcholinesterase inhibitors

Drug Discov Today. 2019 Feb;24(2):629-635. doi: 10.1016/j.drudis.2018.11.012. Epub 2018 Nov 29.

Authors

Lanlan Jing¹, Gaochan Wu¹, Dongwei Kang¹, Zhongxia Zhou¹, Yuning Song², Xinyong Liu³, Peng Zhan⁴

Affiliations

¹ Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, 44 West Culture Road, 250012 Ji'nan, Shandong 250012, PR China.
² Department of Clinical Pharmacy, Qilu Hospital of Shandong University, Jinan 250012, China.
³ Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, 44 West Culture Road, 250012 Ji'nan, Shandong 250012, PR China. Electronic address: [email protected].
⁴ Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, 44 West Culture Road, 250012 Ji'nan, Shandong 250012, PR China. Electronic address: [email protected].

PMID: 30503804
DOI: 10.1016/j.drudis.2018.11.012

Abstract

Butyrylcholinesterase (BChE) is considered a promising drug target for the treatment of moderate to severe Alzheimer's disease (AD). Here, we review medicinal-chemistry strategies that are currently available for the discovery of selective BChE inhibitors.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Alzheimer Disease / drug therapy
Animals
Butyrylcholinesterase / metabolism*
Cholinesterase Inhibitors / chemistry*
Cholinesterase Inhibitors / therapeutic use
Drug Discovery*
Humans

Substances

Cholinesterase Inhibitors
Butyrylcholinesterase