Development of S-Substituted Thioisothioureas as Efficient Hydropersulfide Precursors

Vinayak S Khodade; John P Toscano

doi:10.1021/jacs.8b08469

Development of S-Substituted Thioisothioureas as Efficient Hydropersulfide Precursors

J Am Chem Soc. 2018 Dec 19;140(50):17333-17337. doi: 10.1021/jacs.8b08469. Epub 2018 Dec 6.

Authors

Vinayak S Khodade¹, John P Toscano¹

Affiliation

¹ Department of Chemistry , Johns Hopkins University , Baltimore , Maryland 21218 , United States.

PMID: 30507192
DOI: 10.1021/jacs.8b08469

Abstract

Because of their inherent instability, hydropersulfides (RSSH) must be generated in situ using precursors, but very few physiologically useful RSSH precursors have been developed to date. In this work, we report the design, synthesis, and evaluation of novel S-substituted thiosiothioureas as RSSH precursors. These water-soluble precursors show efficient and controllable release of RSSH under physiological conditions.

Publication types

Research Support, U.S. Gov't, Non-P.H.S.